Optimization of Hydroxypropyl Methylcellulose and Sodium Carboxymethyl Cellulose in Buccal Film Salbutamol Sulphate
Context: Salbutamol sulphate has first pass metabolism in liver and degrade in the colon. That problem could solve by buccal mucoadhesive delivery system. Aims: This study was to determine the effect of using HPMC and SCMC polymers on buccal mucoadhessive preparations. Settings and Design: The optim...
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| Main Authors: | , , , |
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| Format: | Academic Paper |
| Published: |
Annals of Tropical Medicine & Public Health, February 2020. 23(3A),
2020-09-30T04:30:53Z.
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| Subjects: | |
| Online Access: | Get Fulltext |
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| Summary: | Context: Salbutamol sulphate has first pass metabolism in liver and degrade in the colon. That problem could solve by buccal mucoadhesive delivery system. Aims: This study was to determine the effect of using HPMC and SCMC polymers on buccal mucoadhessive preparations. Settings and Design: The optimization was using simplex lattice design with proportion HPMC and SCMC in formula F1 (20:5), F2 (12.5:12.5), and F3 (5:20). Methods and Material: Production of the buccal film was by casting solvent and then optimized in the response of swelling index test, mucoadhesive strength test, and in vitro mucoadhesive residence time. Characterization of optimum formula with FTIR test. Statistical analysis used: ANOVA (p < 0.05) in Simplex lattice by Design Expert version 11.0.1 Results: The result of swelling index test showed F1 < F2 < F3; mucoadhesive strength test showed F1 < F3 < F2; and in vitro residence time test showed F1 < F3 < F2. The optimum formula found in a proportion of HPMC and SCMC (11.346; 13.654) with swelling index 3.985; a mucoadhesive strength of 36.1 gF; and in vitro residence time of 300 min. The results of FTIR analysis showed that there was no chemical interaction that could change the salbutamol sulphate functional group as the active ingredient that related to therapeutic effect. Conclusions: The combination of HPMC and SCMC could give the optimum response in the buccal film preparations. |
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| Item Description: | http://repository.unej.ac.id/handle/123456789/101061 kodeprodi2210101#Farmasi NIDN0003107903 |