Gastrointestinal Variables and Drug Absorption: Experimental, Computational and In Vitro Predictive Approaches

Gastrointestinal Variables and Drug Absorption: Experimental, Computational and In Vitro Predictive Approaches

This book presents some of the state-of-the-art methods for the study of the gastrointestinal variables affecting oral drug absorption. Practical applications of new in vitro release/dissolution methods are presented, as well as in vitro permeability studies to explore segmental differences. The app...

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Bibliographic Details
Main Author: Bermejo, Marival (auth)
Format: Book Chapter
Published: MDPI - Multidisciplinary Digital Publishing Institute 2020
Subjects:
in vitro dissolution
microscopy imaging
modulation
ionotropic gelation
laponite
biowaiver
beads
model
polymer/clay composite
flow
bioequivalence
oral absorption
curcumin
P-gp
liquid-liquid phase separation
absorption
large bowel
dissolution
Ussing chamber
swelling
fimasartan
volume
dexketoprofen
gastrointestinal simulator
transit
controlled release formulations
experimental and computational permeability methods
magnetic resonance imaging
GastroPlus™
in vitro-in vivo correlation (IVIVC)
diltiazem
MRI
gut
in vitro systems
CYP3A4
poorly water-soluble drugs
regional absorption
intestinal permeability
butyric acid
intestinal drug absorption
gastrointestinal absorption
Biopharmaceutics Classification System (BCS)
anti-inflammatory
in vivo
colon microbiota
lipid-based formulations
in situ single-pass perfusion
metabolites
biorelevant media
fluconazole
colon delivery
modeling study
mathematical modeling
motility
gellan gum
gastrointestinal drug release
large intestine
lipolysis
regional drug absorption
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