Pathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy: A Translational Approach

Pathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy: A Translational Approach

Loss of muscle mass and increased fibrosis characterize both sarcopenia of aging and muscular dystrophy. Research is increasingly showing that these two conditions also share several pathophysiological mechanisms, including mitochondrial dysfunction, increased apoptosis, abnormal modulation of autop...

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Bibliographic Details
Main Author: Paolo Bonaldo (auth)
Other Authors: Luciano Merlini (auth), Emanuele Marzetti (auth)
Format: Book Chapter
Published: Frontiers Media SA 2015
Subjects:
Aging sarcopenia
muscular dystrophy
Mitochondrial dysfunction
therapy
skeletal muscle
Autophagy
Animal Models
Apoptosis
satellite cells
muscle imaging
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