Tumor Hypoxia: Impact in Tumorigenesis, Diagnosis, Prognosis and Therapeutics
Hypoxic regions have been identified within tumors and its presence has been linked to malignant progression, metastasis, resistance to therapy, and poor clinical outcomes following treatment. Acute and chronic hypoxia are integral components of tumor microenvironment and conduce to metabolic adapta...
Saved in:
主要作者: | |
---|---|
格式: | 本书章节 |
出版: |
Frontiers Media SA
2017
|
主题: | |
在线阅读: | Get Fullteks DOAB: description of the publication |
标签: |
添加标签
没有标签, 成为第一个标记此记录!
|
LEADER | 03476naaaa2200349uu 4500 | ||
---|---|---|---|
001 | doab_20_500_12854_61392 | ||
005 | 20210212 | ||
020 | |a 978-2-88945-064-0 | ||
020 | |a 9782889450640 | ||
024 | 7 | |a 10.3389/978-2-88945-064-0 |c doi | |
041 | 0 | |a English | |
042 | |a dc | ||
100 | 1 | |a Christian R. Gomez |4 auth | |
245 | 1 | 0 | |a Tumor Hypoxia: Impact in Tumorigenesis, Diagnosis, Prognosis and Therapeutics |
260 | |b Frontiers Media SA |c 2017 | ||
300 | |a 1 electronic resource (113 p.) | ||
506 | 0 | |a Open Access |2 star |f Unrestricted online access | |
520 | |a Hypoxic regions have been identified within tumors and its presence has been linked to malignant progression, metastasis, resistance to therapy, and poor clinical outcomes following treatment. Acute and chronic hypoxia are integral components of tumor microenvironment and conduce to metabolic adaptations of tumor cells leading to genetic instability, intratumor heterogeneity and malignant progression. On the success of our fight against cancer, the continued adaptability of tumors to their microenvironmental stresses, such as hypoxia, must be considered. Tumor cells are endowed with a very high plasticity and capacity to adapt. It is our challenge to find populations and conditions of the tumor microenvironment germane for target success. Interdisciplinary work will be the key for achievement of these goals. This e-book is a compendium of original reports and review articles contributed by world-class experts in the field of tumor hypoxia. This material will be useful to foster discussion and increase understanding of the involvement of hypoxia in tumorigenesis, biomarker development, and therapeutics.Hypoxic regions have been identified within tumors and its presence has been linked to malignant progression, metastasis, resistance to therapy, and poor clinical outcomes following treatment. Acute and chronic hypoxia are integral components of tumor microenvironment and conduce to metabolic adaptations of tumor cells leading to genetic instability, intratumor heterogeneity and malignant progression. On the success of our fight against cancer, the continued adaptability of tumors to their microenvironmental stresses, such as hypoxia, must be considered. Tumor cells are endowed with a very high plasticity and capacity to adapt. It is our challenge to find populations and conditions of the tumor microenvironment germane for target success. Interdisciplinary work will be the key for achievement of these goals. This e-book is a compendium of original reports and review articles contributed by world-class experts in the field of tumor hypoxia. This material will be useful to foster discussion and increase understanding of the involvement of hypoxia in tumorigenesis, biomarker development, and therapeutics. | ||
540 | |a Creative Commons |f https://creativecommons.org/licenses/by/4.0/ |2 cc |4 https://creativecommons.org/licenses/by/4.0/ | ||
546 | |a English | ||
653 | |a microenvironment | ||
653 | |a Stem Cells | ||
653 | |a hypoxia | ||
653 | |a stress | ||
653 | |a HIF | ||
653 | |a tumor | ||
653 | |a Leukemia | ||
653 | |a biomarkers | ||
653 | |a therapy | ||
653 | |a pH | ||
856 | 4 | 0 | |a www.oapen.org |u http://journal.frontiersin.org/researchtopic/3972/tumor-hypoxia-impact-in-tumorigenesis-diagnosis-prognosis-and-therapeutics |7 0 |z Get Fullteks |
856 | 4 | 0 | |a www.oapen.org |u https://directory.doabooks.org/handle/20.500.12854/61392 |7 0 |z DOAB: description of the publication |