Tumor Hypoxia: Impact in Tumorigenesis, Diagnosis, Prognosis and Therapeutics
Hypoxic regions have been identified within tumors and its presence has been linked to malignant progression, metastasis, resistance to therapy, and poor clinical outcomes following treatment. Acute and chronic hypoxia are integral components of tumor microenvironment and conduce to metabolic adapta...
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Frontiers Media SA
2017
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