Role of Genomics in the Management of Hypertension

Role of Genomics in the Management of Hypertension

Arterial hypertension affects about 1 billion people worldwide and it is the strongest modifiable risk factor for cardiovascular disease and related disability. Since the initial discovery of rare monogenic disorders with large effects, the role of genomics has evolved into large genome-wide associa...

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Bibliographic Details
Other Authors: Mulatero, Paolo (Editor), Monticone, Silvia (Editor)
Format: Book Chapter
Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020
Subjects:
Research & information: general
Biology, life sciences
atrial natriuretic peptide
T2238C variant
endothelial dysfunction
smooth muscle cells contraction
platelet aggregation
epigenetics
cardiovascular diseases
renin
low-renin
hypertension
mineralocorticoid receptor
genetics
aldosterone
essential hypertension
blood pressure
genome-wide association studies
exome microarray
next-generation sequencing
rare variants
rare-variants association testing
burden test
sequence kernel association test
hypokalemia
low renin hypertension
monogenic hypertension
Liddle syndrome
SCNN1A
SCNN1B
SCNN1G
non-coding RNA
micro RNA
primary aldosteronism
aldosterone-producing adenoma
transcriptome profiing
DNA methylation
histone modifications
vascular smooth muscle cells
endothelial cells
Kruppel-like factor 15
left ventricular hypertrophy
cardiac hypertrophy
heart failure
genetics of left ventricular hypertrophy
fibromuscular dysplasia
non atherosclerotic vascular stenosis
PHACTR1
genetic association
cervical artery dissection
spontaneous coronary arteries dissection
CRY1
CRY2
HSD3B1
HSD3B2
cardio-tonic steroids
endogenous ouabain
adducin
renal damage
African American
ARMC5
GRK4
CACNA1D
endocrine hypertension
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