Role of Genomics in the Management of Hypertension

Arterial hypertension affects about 1 billion people worldwide and it is the strongest modifiable risk factor for cardiovascular disease and related disability. Since the initial discovery of rare monogenic disorders with large effects, the role of genomics has evolved into large genome-wide associa...

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Övriga upphovsmän:	Mulatero, Paolo (Utgivare, redaktör, sammanställare), Monticone, Silvia (Utgivare, redaktör, sammanställare)
Materialtyp:	Bokavsnitt
Publicerad:	Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020
Ämnen:	Research & information: general Biology, life sciences atrial natriuretic peptide T2238C variant endothelial dysfunction smooth muscle cells contraction platelet aggregation epigenetics cardiovascular diseases renin low-renin hypertension mineralocorticoid receptor genetics aldosterone essential hypertension blood pressure genome-wide association studies exome microarray next-generation sequencing rare variants rare-variants association testing burden test sequence kernel association test hypokalemia low renin hypertension monogenic hypertension Liddle syndrome SCNN1A SCNN1B SCNN1G non-coding RNA micro RNA primary aldosteronism aldosterone-producing adenoma transcriptome profiing DNA methylation histone modifications vascular smooth muscle cells endothelial cells Kruppel-like factor 15 left ventricular hypertrophy cardiac hypertrophy heart failure genetics of left ventricular hypertrophy fibromuscular dysplasia non atherosclerotic vascular stenosis PHACTR1 genetic association cervical artery dissection spontaneous coronary arteries dissection CRY1 CRY2 HSD3B1 HSD3B2 cardio-tonic steroids endogenous ouabain adducin renal damage African American ARMC5 GRK4 CACNA1D endocrine hypertension
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Role of Genomics in the Management of Hypertension

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