Hereditary Hemorrhagic Telangiectasia : Recent Advances and Future Challenges

Hereditary Hemorrhagic Telangiectasia : Recent Advances and Future Challenges

Hereditary hemorrhagic telangiectasia (HHT) is an inherited disease that affects the blood vessels, and is characterized by direct connections between arteries and veins with no intervening capillaries. These abnormal vessels may appear in the skin as tiny red dilated blood vessels in the mouth, lip...

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Bibliographic Details
Other Authors: Mager, Hans-Jurgen (Editor), Bernabeu, Carmelo (Editor), Post, Marco (Editor)
Format: Book Chapter
Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
Subjects:
Research & information: general
hereditary hemorrhagic telangiectasia
rare diseases
telangiectasis
transforming growth factor-beta (TGF-β)
Smad pathway
gastrointestinal bleeding
epistaxis
nosebleeds
tacrolimus
nasal ointment
genetic disease
rare disease
hereditary hemorrhagic telangiectasia (HHT)
telangiectases
mechanical damage
sun-induced trauma
vascular malformations
Endoglin
activin-receptor-like kinase 1
Hereditary Hemorrhagic Telangiectasia
antithrombotic therapy
anticoagulants
antiplatelets
bleeding
safety
HHT
ALK1
endoglin
raloxifene
bazedoxifene
tranexamic acid
propranolol
FK506
etamsylate
N-acetylcysteine
pulmonary arteriovenous malformations
transcatheter embolotherapy
screening
guidelines
Hereditary hemorrhagic telangiectasia
pediatrics
genotype-phenotype correlation
arteriovenous malformation
ENG
ACVRL1
SMAD4
microRNA
biomarker
plasma
arteriovenous malformations (AVMs)
angiogenesis
activin receptor-like kinase 1 (ALK1)
transforming growth factor beta (TGF-β)
bone morphogenetic protein (BMP)
propranolol gel
epistaxis severity score
nasal endoscopy
antiangiogenic properties
non-coding RNAs
microRNAs
long non-coding RNAs
biomarkers
endothelial cells
hereditary hemorrhagic telangiectasia (HHT), second-hit
arteriovenous malformation (AVM)
Smad4
inflammation
shear stress
vascular injury
somatic mutation
cell adhesion
vascular endothelial growth factor (VEGF)
telangiectasia
hereditary hemorrhagic
survival
life expectancy
pulmonary arteriovenous malformation
contrast enhanced magnetic resonance angiography
liver
MRI
ultrasound
AVM
bevacizumab
Osler-Weber-Rendu
hereditary hemorrhagic telangiectasia/HHT/osler's disease
cerebral ischemic lesions
catheter based embolization therapy
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