Molecular Mechanisms of Sensorineural Hearing Loss and Development of Inner Ear Therapeutics

Molecular Mechanisms of Sensorineural Hearing Loss and Development of Inner Ear Therapeutics

The sense of hearing is vulnerable to environmental challenges, such as exposure to noise. More than 1.5 billion people experience some decline in hearing ability during their lifetime, of whom at least 430 million will be affected by disabling hearing loss. If not identified and addressed in a time...

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Bibliographic Details
Other Authors: Vlajkovic, Srdjan M (Editor)
Format: Book Chapter
Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
Subjects:
Medicine
brain-derived neurotrophic factor
TrkB
inner ear
development
zebrafish
mitochondria dysfunction
reactive oxygen species
hypoxic
d-galactose
high-fat diet
aging
hearing loss
astrocytes
auditory brainstem
lateral superior olive
gap junctions
voltage-activated calcium channel 1.3
otoferlin
spontaneous activity
deafness
circadian dysregulation
clock genes
noise-induced hearing loss
sensory hair cells
synaptic ribbons
sensorineural hearing loss
hyperbaric oxygenation
adjunctive therapy
microRNAs
cochlear nucleus
inferior colliculus
neuroplasticity
noise-induced cochlear injury
cochlear rescue
otoprotection
adenosine A1 receptor
regulator of G protein signalling 4
CCG-4986
intratympanic drug delivery
potassium voltage-gated channel subfamily q member 4
potassium
nonsyndromic hearing loss
KCNQ4 activator
age-related hearing loss
selegiline
chronic oral treatment
hearing protection
mouse model
n/a
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